TGI Best Advice: Share Knowledge & Save A Life

References: TGI: Antibiotic Resistant Bacteria – know the presence of ASURAS with-in October 23, 2013 The Centers for Disease Control and Prevention (CDC) released its “landmark” report on the rising and lethal threat of antibiotic resistance, titled Antibiotic Resistance Threats in the United States, 2013. The report describes a complex problem and the steps that must […]

Always Good To Remember

Science-based Approach Following three strategies for both cancer prevention and weight loss are similar. Strategies for Cancer Prevention: 1. Eat mostly plant-based foods, which are low in energy density 2. Be physically active 3. Maintain a healthy weight (via steps 1 and 2, as well as reducing portion size) Strategies for Weight Loss: 1. Eat […]

You Already Know How to Defeat Cancer

There are more than 100 types of Cancers. To learn about them go to: cancer.org. It appears that there is not much to panic, because the matter of the fact is that if we look at what causes cancer, it is very obvious that majority of the cancers are preventable. Look at WHAT CAUSES CANCER Inherited (Hereditary) – about […]

Cancer

Cancer is a broad group of various diseases involving unregulated cell growth. It is medically known as a malignant neoplasm. In cancer, cells divide and grow uncontrollably and invade nearby parts of the body. The cancer may also spread to more distant parts of the body through the lymphatic system or bloodstream, it is called […]

Magnesium

Role of Magnesium in maintaining Blood Pressure and over-all well-being Magnesium an abundant mineral in the body, is naturally present in many foods, added to other food products, available as a dietary supplement, and present in some medicines (such as antacids and laxatives). Magnesium is a cofactor in more than 300 enzyme systems that regulate […]

Consuming sesame-based ingredients may reduce oxidative stress

The antioxidant boosting properties of sesame, and especially sesame oil, can have a significant effect on oxidative stress, improving human health, according to a systematic review published in Journal of Medicinal Food, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Source: Consuming sesame-based ingredients may reduce oxidative stress

Potato-Heavy Diet Linked to High Blood Pressure

A new study in The BMJ on more than 187,000 people found that eating more potatoes was associated with an increased risk for hypertension. Source: Potato-Heavy Diet Linked to High Blood Pressure

(Genetic) CrosstalK: Obesity -> Inflammation -> Cancer

It remains unclear how obesity worsens treatment outcomes in patients with pancreatic ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes inflammation and fibrosis. We found in mouse models of PDAC that obesity also promotes desmoplasia associated with accelerated tumor growth and impaired delivery/efficacy of chemotherapeutics through reduced perfusion. Genetic and pharmacological inhibition of angiotensin-II type-1 […]

RGD peptide-conjugated selenium nanoparticles: antiangiogenesis by suppressing VEGF-VEGFR2-ERK/AKT pathway – Nanomedicine: Nanotechnology, Biology and Medicine

ngiogenesis is essential for tumorigenesis, progression and metastasis. Herein we described the synthesis of RGD peptide-decorated and doxorubicin-loaded selenium nanoparticles (RGD-NPs) targeting tumor vasculature to enhance the cellular uptake and antiangiogenic activities in vitro and in vivo. After internalization by receptor-mediated endocytosis, this nanosystem disassembled under acidic condition with the presence of lysozymes and cell […]

Evaluation of endocytosis of silica particles used in biodegradable implants in the brain – Nanomedicine: Nanotechnology, Biology and Medicine

Silica nanoparticles embedded in a biodegradable scaffold have been proposed to offer several advantages when used in laser-tissue-soldering of blood vessels in the brain. During degradation, these nanoparticles are likely to be released into the surrounding brain tissue. The aim of this study was to investigate possible cellular uptake mechanism(s) of the two silica nanoparticle […]

Catanionic lipid nanosystems improve pharmacokinetics and anti-lung cancer activity of curcumin – Nanomedicine: Nanotechnology, Biology and Medicine

  Novel catanionic lipid nanosystems (CLNs) incorporating curcumin (CCM) were developed, and improvements in pharmacokinetics and enhanced anti-lung cancer activity were observed. CCM was present in a lipid matrix surrounded by cationic, anionic and zwitterionic surfactants, forming the core-shell nanosystems. Compared with free CCM, the CCM-CLNs had much higher oral and intravenous bioavailabilities due to […]