A New Microscopic Technique To Better Understanding of Human Tissues and other Biomedical Materials

· TGI - Medical Physics

A ‘proof of concept’ study showed that a relatively new microscopy technique can be used to improve our understanding of human tissues and other biomedical materials.

Proliferative retinopathy Description: Prolife...

Proliferative retinopathy Description: Proliferative retinopathy, an advanced form of diabetic retinopathy, occurs when abnormal new blood vessels and scar tissue form on the surface of the retina. Credit: National Eye Institute, National Institutes of Health Ref#: EDA01 (Photo credit: Wikipedia)

The study focused specifically on eye tissues, which are damaged by scarring in diabetic patients. This technique is extremely effective at giving us the data we need on these tissues,” says Dr. Albena Ivanisevic, co-author of a paper who is an associate professor of materials science and engineering at NC State and associate professor of the joint biomedical engineering program at NC State and the University of North Carolina at Chapel Hill.

“Specifically, it gives a great deal of information on the composition of these tissues, as well as the tissue’s topography, or surface characteristics” they added.

There are multiple treatments for scar tissue formation. In the United States, a common technique is for a surgeon to peel off the  inner limiting membrane (ILM), removing the scar tissue with it. In many other parts of the world, surgeons inject dye into the eye to better distinguish the parts of the eye they will operate on.

(This process is not currently allowed in the United States, due to concerns about the dye’s toxicity)

The researchers launched a project to determine if bimodal dual AC mode microscopy could be used to provide a better understanding of the topographical properties of the ILM. Further, they wanted to use the technology to see if it offered insight into how—or whether—various dyes affect the topographical characteristics of the ILM. “All of this information could be used to improve surgical outcomes and to foster research into additional treatments for the condition,” Ivanisevic says.

The researchers found that bimodal dual AC mode microscopy, an atomic force imaging technique, captured the properties of the tissue in exceptional detail. Atomic force imaging effectively runs a probe over the surface of a material to collect data on its topography, similar to the way in which a record player’s needle runs over the surface of an album.

“The next step would be to use this technology to assess the utility—and potential risk—of various dyes,” Ivanisevic says. “If we can find a dye that is extremely effective and poses little risk, it may be approved for use in future surgeries.”


1 Comment

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  1. laboratory microscopes

    Great share friend. I have read all your post here and found it interesting to read. In fact i was able to take note all of the valuable information i was gathered specially on understanding human tissue and other biomedical materials. Thanks


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