Modification of the target environment for improving the tumor uptake of the nanoparticles: a radiation-induced decrease in tumor interstitial pressure and a subsequent increase in vascular permeability.

· TGI - Nano & Beyond
Authors

Nanoparticle-based therapies are currently being explored for both the imaging and treatment of primary and metastatic cancers. Effective nanoparticle cancer therapy requires significant accumulations of nanoparticles within the tumor environment.

Various techniques have been used to improve tumor nanoparticle uptake and biodistribution. Most notable of these techniques is the use of tumor-specific peptide-conjugated nanoparticles and chemical modification of the nanoparticles with immune-evading polymers.

Another strategy for improving the tumor uptake of the nanoparticles is modification of the tumor micro environment with a goal of intensifying the enhanced permeability and retention effect inherent to solid tumors.

They demonstrated a twofold increase in the tumor accumulation of systemically delivered iron oxide nanoparticles following a single 15-Gy radiation dose in a syngeneic mouse breast tumor model.

This increase in nanoparticle tumor accumulation correlates with a radiation-induced decrease in tumor interstitial pressure and a subsequent increase in vascular permeability.

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