Growth, body composition and metabolic profile of 8-year-old children exposed to metformin in utero.
Patients and methods.
This is a follow-up study of a randomized, controlled trial on PCOS women, randomized to metformin or placebo in pregnancy.
Out of 37 children aged 7-9 years, 25 agreed to participate.
Primary outcome measures were growth, body composition and metabolic parameters.
There were no differences in height, weight or body composition between those exposed to metformin and those exposed to placebo.
They found a higher fasting glucose level in the metformin group (4.93 mmol/L vs. 4.60 mmol/L, p = 0.04).
Metformin exposure during fetal life does not seem to influence growth and body composition at the age of 8 years.
A higher fasting glucose level and a possible higher systolic blood pressure and lower LDL cholesterol level in the metformin group may be coincidental and should be further explored.
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