This study was conducted by Tran et.al., at UC Davis and this study is to determine the clinical value of multiplex polymerase chain reaction (PCR) study for enhancing pathogen detection in patients with suspected septicemia after trauma, emergency, and burn surgery.
Though results warrant further investigation through interventional trials, the following are the noteworthy as far multiplex PCR is concerned:
- PCR detected the presence of pathogens more frequently than blood culture
- Faster results were reported compared to blood culture results.
- Severity scores were significantly greater in PCR-positive trauma and emergency surgery patients.
- The lack of pathogen DNA as determined by PCR served as a significant predictor of survival in the combined patient population.
- PCR testing independent of traditional prompts for culturing may have clinical value in burn patients.
Seen first at PI posted by Dr. Larry H Bernstein, MD, FCAP : Molecular pathogen identification comes to the bedside
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