When normal cells divide, the chromosomes, i.e. the genetic material, are distributed evenly to exactly two daughter cells. This process is regulated by two polar bodies, or centrosomes. When cell division begins, they are located at the opposite poles of the cell and they start forming protein fibers to each chromosome. These are then each pulled under tension to one of the poles and, thus, distributed evenly to the two newly forming daughter cells.
Cancer cells often have too many centrosomes. This should normally make it impossible for them to divide correctly and, as a result, lead to their death, but most of them have developed a trick to escape this fate.
Problem: They form clusters of polar bodies at two poles.
Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now developed a substance (GF-15) that thwarts this trick and forces cancer cells into death during cell division.
The substance was effective in various cell lines derived from such different types of cancer as colon cancer, cervical cancer, brain tumors, and blood cancer.
Plausible Solution: “The optimized agent GF-15 reduces the tension of the protein fibers and thus prevents clustering.
The group has reported their results in the journal Cancer Research (Cancer Res. 2012 Aug 31)
Read more at:
- Well-known protein reveals new tricks (eurekalert.org)
- This Vegetable Could Kill Cancer? (belmarrahealth.com)
- AZD1480 Blocks Growth and Tumorigenesis of RET- Activated Thyroid Cancer Cell Lines (plosone.org)
- The Mitosis Process (slideshare.net)
- Fruity Breakfast Lentils (psychologytoday.com)
- Well-known protein reveals new tricks (universityofcalifornia.edu)
- The Effect of Sugar on Cancer (belmarrahealth.com)