Medication Exposure in Pregnancy Risk Evaluation Program

· TGI - Gestation, TGI - Health
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i take drugs

i take drugs (Photo credit: the|G|™)

Decision-making regarding safe use of medications during pregnancy is challenging for a number of reasons. Pregnant women are generally excluded from clinical trials for ethical concerns about the drug’s impact upon the developing fetus. The lack of rigorous post-marketing studies evaluating birth outcomes associated with in utero exposure to most medications is unfortunate, and limits the ability of physicians and patients to make fully informed decisions about the risks and benefits of medications during pregnancy.

To bridge the gap “Medication Exposure in Pregnancy Risk Evaluation Program (MEPREP)” has been developed. MEPREP is a multi-site collaborative research program developed to enable the conduct of studies of medication use and outcomes in pregnancy.

Collaborators include the:

U.S. Food and Drug Administration

HMO Research Network,

– Kaiser Permanent Northern and Southern California, and

Vanderbilt University.

MEPREP currently involves more than 20 medication safety researchers and includes data for 1,221,156 children delivered to 933,917 mothers. Current studies include evaluations of the prevalence and patterns of use of specific medications and a validation study of data elements in the administrative and birth certificate data files. MEPREP can support multiple studies by providing information on a large, ethnically and geographically diverse population.

This partnership combines clinical and research expertise and data resources to enable the evaluation of outcomes associated with medication use during pregnancy.

A major focus of MEPREP’s research agenda may include studies of the association between in utero exposure to specific medications and congenital anomalies or other birth outcomes (e.g., preterm birth).

Specific medication classes of interest to program researchers include:

– Opioids,

Anti-infectives (including antivirals),

– Asthma medications,

Antidiabetics,

– Antipsychotics, and

Antiepileptics.

There is a strong hope and high expectations that the linked datasets developed as part of MEPREP allow the analysis of comparable data across multiple sites and improve computer programming efficiency and accuracy. Research conducted through this partnership will provide valuable information for patients and physicians when making decisions about medication during pregnancy.

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7 Comments

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  1. TGI

    Taking into account the deep acting nature of both Puls and Si, it may be recommended not to repeat in general.

    Is it advisable to consider LM potency in case situation arises where in which one has to repeat homeopathic remedies during pregnancy? that includes Puls, Si, Sepia, Nux-v, Ipec, Colch, Nat. Carb, Ars, Merc, Nit.ac, Hepar, Caust, tissue salts etc.?

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  2. Alan V. Schmukler

    Silica is usually contraindicated and Pulsatilla only before the 3rd trimester, when it can be used above 30c. There are a couple others as well, but they are not readily available. I will not go into the various explanations. People using homeopathy during pregnancy should have some idea how to use homeopathy, but they don’t have to be experts.

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    • TGI

      Thank you for the info. It is good to know that there are not many remedies that contraindicate in pregnancy. At the same time it is interesting to note Puls and Silica. And Silicea Terra is considered chronic of Puls and if I remember well silica is already present in Puls as Puls plant is grown in sandy soils. Is it true?

      What I understood from the comment is that, in general, lower potency is the safest one in pregnancy. Is it the case?

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      • Alan V. Schmukler

        The potency issue is too involved to explain in this bried comment. Amateurs are generally safe with 30c. It’s important to know when to repeat and when not to .

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  3. TGI

    Thank you, sir, for the comments.

    Is it true that there are some remedies in homeopathy that are contraindicated in pregnancy? If so may I request for the list of those remedies, with possible explanation why so?

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  4. Alan V. Schmukler

    All of the drugs being reviewed for their safety during pregnancy can be substituted for homeopathic remedies which have none of the dangerous side effects of pharmaceutical. They work safely and are curative instead of being suppressive. There’s no need to reinvent the wheel here. Safe homeopathic medicine already exist.

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