Biomarkers linked to Alzheimer’s were apparent at least 20 years before the onset of symptoms

· TGI - Health, Uncategorized
Authors

Auguste Deter. Alois Alzheimer's patient in No...

Alzheimer’s is a key area of focus for the pharmaceutical industry, but drug development efforts have had little success with many researchers suggesting that by the time patients present with symptoms the disease may be too far progressed to treat effectively.

It’s hoped that early detection biomarkers could enable identification of pre-symptomatic Alzheimer’s patients and improve their therapeutic options.

In a study published in The Lancet Neurology, a team of researchers found that biomarkers linked to Alzheimer’s were apparent at least 20 years before the onset of symptoms.

The findings came from a study of young adults from a population in Colombia with a high prevalence of a mutation in the presenilin 1, or PSEN1, gene, which leads to the development of Alzheimer’s at an early age. In an analysis of 44 subjects — 20 who carried the mutation and 24 who did not — the researchers found differences in brain structure and function between the two groups.

See below “The shrunken brain of an Alzheimer’s patient compared with a healthy one”.

They also found increased cerebrospinal fluid levels of amyloid beta — an established protein biomarker for Alzheimer’s — in mutation carriers well in advance of clinical onset of the disease.

1. genomeweb

2. Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer’s disease in the presenilin 1 E280A kindred: a case-control study

Related literature on Alzheimer’s from TGI:

Pl. note the signs of dementia

  • Struggling to remember recent events
  • Problems following conversations
  • Forgetting the names of friends or objects
  • Repeating yourself
  • Problems with thinking or reasoning
  • Confusion in familiar places

  According to the Pharmaceutical Research and Manufacturers of America (PhRMA) drug developers have scrapped or halted development of 101 meds for the complex disorder “Alzheimer’s” and brought to market only three treatments for symptoms of the disease. This should come as no surprise to those who have followed the recent late-stage disasters of Johnson & Johnson ($JNJ) […]

  In a recent study, investigators at Boston University Schools of Medicine (BUSM) and Public Health (BUSPH) identified a gene linking age-related cataracts and Alzheimer’s disease. The findings, published online in PLoS ONE, contribute to the growing body of evidence showing that these two diseases, both associated with increasing age, may share common etiologic factors. […]

Pathological aging (PA) is used to describe the brains of people which have Alzheimer’s disease (AD)-like pathology but where the person showed no signs of cognitive impairment whilst they were alive. New research shows that PA and AD brains contain similar amyloid β () plaques and that while on average AD brains contain more Aβ there was considerable overlap […]

Alzheimer’s it is the most common form of dementia it is also known as simply Alzheimer’s, and Senile Dementia of the Alzheimer Type (SDAT) it’s a progressive neurologic disease of the brain i.e., the disease gets worse as it develops amyloid plaques develop within the structure of the brain resulting brain cell death causes irreversible loss of neurons, loss of intellectual abilities, […]

  Steroid hormones are synthesized in steroidogenic cells of the adrenal gland, ovary, testis, placenta, and brain and are required for normal reproductive function and body homeostasis. Steroid synthesis is regulated by trophic hormones, specifically, adrenocorticotropin hormone (ACTH) in adrenocortical cells and luteinizing hormone (LH) in testicular Leydig and ovarian cells respectively.   These hormones […]

Effects of copper nanoparticles on cerebral endothelial cells: A size dependent activity – proliferation at low concentrations and neurotoxicity at high concentrations. Nanomedicine June 2012, Vol. 7, No. 6, Pages 835-846 , DOI 10.2217/nnm.11.154 (doi:10.2217/nnm.11.154) Article: Effects of copper nanoparticles on rat cerebral microvessel endothelial cells. William J Trickler1, Susan M Lantz1, Amanda M Schrand2, Bonnie L Robinson1,Glenn […]

Researchers from the University of Ulm, among them the Epidemiologist Professor Gabriele Nagel and the Neurologist Professor Christine von Arnim, have discovered that the serum-concentration of the antioxidants vitamin C and beta-carotene are significantly lower in patients with mild dementia than in control persons. It might thus be possible to influence the pathogenesis of AD […]

Reported by: Dr. Venkat S Karra, Ph.D. Single infection before birth (during late gestation) was enough to induce long-term neurological changes and significant memory problems at old age says recent research published in Biomed Central‘s open access Journal of Neuroinflammation. It suggests that chronic inflammation can predispose the brain to develop Alzheimer’s disease. Researchers from the University of Zurich, […]

Curated by: Dr. Venkat S Karra, Ph.D. Metals are an environmental toxin and at the same time they also have therapeutic value, e.g., like the platinum in cisplatin that treats prostate cancer. Also metals such as copper, zinc, and iron are important nutrients -the special properties of these elements that make them useful to living organisms. For example, copper […]

  A team of engineers and students at the University of Rhode Island (URI) has developed an advanced blood-testing technology that incorporates a smartphone application, a handheld biosensor, and a credit card-sized cartridge to provide rapid, accurate biological analysis and wireless communication of test results. This lab-on-a-chip technology improves upon a previous system announced by […]

Aβ vaccinationhas been shown to induce remarkable clearance of brain amyloid plaques in mouse models of Alzheimer’s disease (AD). However, the extent to which antibody-mediated Aβ clearance is affected by predominant formation of Aβ42 over Aβ40 is unclear. It was demonstrated for the first time that in a mouse model carrying the human APP mutations KM670/671NL and the human PS1 […]

Prevention is Better than Cure Prevention well before a disease becomes evident is obviously the most prefered approach especially in health matters because “Health is Prosperity”. Now researchers, institutions and industries are making exactly one such attempt. The trial will be financed with $16 million from the National Institutes of Health, $15 million from private […]

6 Comments

Comments RSS

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: