Biomarkers linked to Alzheimer’s were apparent at least 20 years before the onset of symptoms

· TGI - Health, Uncategorized

Auguste Deter. Alois Alzheimer's patient in No...

Alzheimer’s is a key area of focus for the pharmaceutical industry, but drug development efforts have had little success with many researchers suggesting that by the time patients present with symptoms the disease may be too far progressed to treat effectively.

It’s hoped that early detection biomarkers could enable identification of pre-symptomatic Alzheimer’s patients and improve their therapeutic options.

In a study published in The Lancet Neurology, a team of researchers found that biomarkers linked to Alzheimer’s were apparent at least 20 years before the onset of symptoms.

The findings came from a study of young adults from a population in Colombia with a high prevalence of a mutation in the presenilin 1, or PSEN1, gene, which leads to the development of Alzheimer’s at an early age. In an analysis of 44 subjects — 20 who carried the mutation and 24 who did not — the researchers found differences in brain structure and function between the two groups.

See below “The shrunken brain of an Alzheimer’s patient compared with a healthy one”.

They also found increased cerebrospinal fluid levels of amyloid beta — an established protein biomarker for Alzheimer’s — in mutation carriers well in advance of clinical onset of the disease.

1. genomeweb

2. Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer’s disease in the presenilin 1 E280A kindred: a case-control study

Related literature on Alzheimer’s from TGI:

Pl. note the signs of dementia

  • Struggling to remember recent events
  • Problems following conversations
  • Forgetting the names of friends or objects
  • Repeating yourself
  • Problems with thinking or reasoning
  • Confusion in familiar places

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