Large-Scale Carbonyl Reductions in the Pharmaceutical Industry

· TGI - General

Researchers from Chemical Research and Development, Pharmaceutical SciencesPfizer Worldwide Research and Development, United States have presented a review on a large-scale carbonyl reductions in the pharmaceutical industry.

The article was published in Org. Process Res. Dev., 2012, 16 (6), pp 1156–1184 DOI10.1021/op2003826


Abstract Image

Herein authors presented a review on methods for carbonyl reductions on large scale (≥100 mmol) applied to the synthesis of drug candidates in the pharmaceutical industry. The most common and reliable methods for the reduction of aldehydes, ketones, carboxylic acids, esters, amides, imides, and acid chlorides were discussed. Representative examples illustrate detailed reaction and workup conditions and highlight the advantages and limitations of each reducing agent with special emphasis on safety, cost, and amenability to scale-up.



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