New Manufacturing Procedure of Cetirizine

· TGI - General, TGI - Health
Authors

Researchers from EGIS Pharmaceuticals Plc., Chemical Research Division, and Small Scale API Production Plant in Budapest, Hungary have developed a new manufacturing procedure of cetrizine.

Citrizine is a second generation antihistamine and is  used in the treatment of allergieshay feverangioedema, and urticaria.

The article was published in Org. Process Res. Dev., 2012, 16 (7), pp 1279–1282 DOI10.1021/op300009y

Abstract

Abstract Image

A new procedure for the manufacture of cetirizine dihydrochloride via the new intermediate 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)-N,Ndimethylacetamide dihydrochloride, synthesized by O-alkylation of 2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethanol with 2-chloro-N,N-dimethylacetamide, is elaborated. Hydrolysis of the resulting amide and subsequent salification provided cetirizine dihydrochloride.

source

ACS

2 Comments

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  1. assuresh

    essential to know process development people

    Like

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