In this paper, adenosine triphosphate (ATP) surface-functionalized selenium nanoparticles are discussed as cell-penetrating anticancer agents. Conjugates are stable and ATP functionalization greatly enhances the apoptosis induction properties of the selenium nanoparticles in HepG2 human hepatocellular carcinoma cells.
ATP surface decoration significantly enhances the cellular uptake and anticancer activity of SeNPs. Induction of apoptosis was the major mode of cancer cell death induced by SeNPs@ATP. Results demonstrate that it is a novel strategy to use ATP as a surface decorator of SeNPs to achieve anticancer synergism. SeNPs@ATP may be a candidate for further evaluation as a therapeutic agent for human cancers.
- Scientists Create Nanoparticle Factories to Amplify Cancer Biomarkers (medgadget.com)
- Peptide-Coated Nanoparticles Offer Early Cancer Detection in Urine (dailytech.com)
- Nanoparticles amplify cancer tumor signals, making them much easier to detect (nextbigfuture.com)
- First-of-its-kind self-assembled nanoparticle for targeted and triggered thermo-chemotherapy (nanowerk.com)
- Researchers Find A Fungus That Could Fight Cancer (medicalnewstoday.com)
- Carnivorous fungus may help fight cancer (bio230fall2010.wordpress.com)
- Flesh-eating fungus produces cancer-fighting nanoparticles (nanowerk.com)