Functionalized Selenium Nanoparticles and Increased anti-cancer activity


In this paper, adenosine triphosphate (ATP) surface-functionalized selenium nanoparticles are discussed as cell-penetrating anticancer agents. Conjugates are stable and ATP functionalization greatly enhances the apoptosis induction properties of the selenium nanoparticles in HepG2 human hepatocellular carcinoma cells.

Graphical abstract:

ATP surface decoration significantly enhances the cellular uptake and anticancer activity of SeNPs. Induction of apoptosis was the major mode of cancer cell death induced by SeNPs@ATP. Results demonstrate that it is a novel strategy to use ATP as a surface decorator of SeNPs to achieve anticancer synergism. SeNPs@ATP may be a candidate for further evaluation as a therapeutic agent for human cancers.




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