Metabolic imbalance is often caused by elevated carbohydrate intake, which can lead to over-activating a molecule called C-terminal binding protein (CtBP).
This over-activation, in turn, can increase the risk of breast cancer.
“Modifying diet and maintaining a healthy diet, combined with developing pharmacological ways of lessening CtBP activity, could be the possible solution to break the link between cancer and obesity.”
“Our new work suggests that targeting CtBP may provide a way of treating breast cancer and possibly preventing breast cancer,” said Gardner, head of NCI’s Transcription Regulation Section, Genetics Branch.
“Research should continue to focus on the link between obesity, CtBP and breast cancer. This will require more population-based studies and multi-disciplinary teams of scientist to investigate these links.”
Results of their work appeared in Nature Communications, Feb. 5, 2013.