Amyloid accumulation: preventive or degenerative ?

· TGI - Biomarkers, TGI - Health
Authors

Steinman’s research at Stanford University has found a physiological basis for amyloid, leading many to ask if amyloid riddles brains of AD patients because it is trying to halt AD—not cause it.

Loma Linda University neurologist Salvador Soriano agrees, “The amyloid hypothesis just assumes amyloid is a toxic byproduct…and assumes getting rid of it will solve the problem. But for several years now that notion has proven wrong.”

Key players in the Alzheimer’s disease (AD) field are moving to Plan B, following the failure of seven big clinical trials of drugs targeting amyloids (misfolded proteins). Plan B involves giving those same drugs to healthy, at-risk people, not patients with established AD as in the failed trials. Three multi-million dollar trials will soon give anti-amyloids to healthy folk. The U.S. Food and Drug Administration (FDA) is on board.

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