Anti-agglomirating effect of Mannitol – could be a good news to PD patients


Researchers from Tel Aviv University say that Mannitol could prevent ‘aggregation of toxic proteins’ in the brain-a complication in Parkinson’s Disease.Illustration of the Parkinson disease by Sir W...

chemical structure of mannitol

Mannitol is a sugar alcohol used in sugar-free gum and candy.

FDA also approved its use in medical field as a diuretic to flush out excess fluids and used during surgery as a substance that opens the blood/brain barrier to ease the passage of other drugs.


A possibility to reconsider the PD medications again that could not cross BBB earlier, because Mannitol has the ability to open the BBB by temporarily shrinking the endothelial cells, simultaneously stretching the tight junctions between the cells – the newly formed gap stays widely open for thirty minutes (1,2).


Risks involved with non-PD medications when using Mannitol & its combinations is not clear.

The results of this study were published in the Journal of Biological Chemistry.

A word of CAUTION from the authors:

Authors say it is still not advisable for Parkinson’s patients to begin ingesting mannitol in large quantities as more testing must be done to determine dosages that would be both effective and safe.

Read more

  1. Ikeda, M.; Bhattacharjee, A. K.; Kondoh, T.; Nagashima, T.; Tamaki, N. Synergistic Effect of Cold Mannitol and Na+/Ca2+ Exchange Blocker on Blood-Brain Barrier Opening. Biochem. Biophys. Res. Commun. 2002, 291, 669–674.
  2. Wang, M.; Etu, J.; Joshi, S. Enhanced disruption of the blood brain barrier by intracarotid mannitol injection during transient cerebral hypoperfusion in rabbits. J. Neurosurg. Anesthesiol. 2007, 19, 249–256.

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