Magnesium

· TGI - Health
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Role of Magnesium in maintaining Blood Pressure and over-all well-being

Magnesium an abundant mineral in the body, is naturally present in many foods, added to other food products, available as a dietary supplement, and present in some medicines (such as antacids and laxatives). Magnesium is a cofactor in more than 300 enzyme systems that regulate diverse biochemical reactions in the body, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation [1-3]. Magnesium is required for energy production, oxidative phosphorylation, and glycolysis. It contributes to the structural development of bone and is required for the synthesis of DNA, RNA, and the antioxidant glutathione. Magnesium also plays a role in the active transport of calcium and potassium ions across cell membranes, a process that is important to nerve impulse conduction, muscle contraction, and normal heart rhythm.

Habitually low intakes of magnesium induce changes in biochemical pathways that can increase the risk of illness over time. This section focuses on four diseases and disorders in which magnesium might be involved: hypertension and cardiovascular disease, type 2 diabetes, osteoporosis, and migraine headaches.

Early signs of magnesium deficiency include loss of appetite, nausea, vomiting, fatigue, and weakness. As magnesium deficiency worsens, numbness, tingling, muscle contractions and cramps, seizures, personality changes, abnormal heart rhythms, and coronary spasms can occur. Severe magnesium deficiency can result in hypocalcemia or hypokalemia (low serum calcium or potassium levels, respectively) because mineral homeostasis is disrupted.

A meta-analysis, funded by the Indiana University School of Medicine Strategic Research Initiative, details positive results that show an association between a daily intake of magnesium and a reduction in blood pressure.

Magnesium is already recognized as essential for over 300 biochemical reactions in the body.

While there has been ongoing research into whether magnesium has a significant effect on high blood pressure, it has been widely documented to maintain normal nerve and muscle function, maintain a steady heartbeat, support a healthy immune system, and help bones to remain strong.

The researchers found that those participants who had a median of 368 mg of magnesium daily for an average of 3 months recorded a decrease in systolic blood pressure of 2.00 mm Hg and a decrease in diastolic blood pressure of 1.78 mm Hg.

“With its relative safety and low cost, magnesium supplements could be considered as an option for lowering blood pressure in high-risk persons or hypertension patients.” says Yiqing Song, M.D., Sc.D., lead author, Indiana University, Indianapolis

Song and colleagues also observed that patients who had an intake of 300 mg of magnesium per day had elevated blood magnesium levels and reduced blood pressure within a month.

Elevated blood magnesium levels were associated with an improvement in blood flow, which has been named as a factor linked to lowered blood pressure.

Read more of this study here: http://www.medicalnewstoday.com/articles/311571.php

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