Gut microbiome is a powerful regulator of disease and health and has been implicated in conditions ranging from inflammatory bowel disease to multiple sclerosis. Gut microbes engage in an intricately choreographed conversation with the immune system, stimulating it just enough to keep disease-causing invaders at bay, while at the same time reining it in so it doesn’t mistakenly launch an attack on the body. There are some 100 trillion bacteria, comprising between 250 and 500 species in the human gut.
For the first time, scientists from Harvard Medical School have managed to “listen in” on the crosstalk between individual microbes and the entire cast of immune cells and genes expressed in the gut. The experiments, published Feb. 16 in Cell, provide a blueprint for identifying important microbial influencers of disease and health and can help scientists develop precision-targeted treatments.
The coagulation system protects our bodies from excessive loss of blood from a leaky or damaged vessel, whereas the immune system protects us from invading pathogens such as viruses. Unexpected links between these two systems suggest their coevolution. Doronin et al. show that an essential protein for the clotting process binds to a virus that has entered […]
Women’s health is a cause for concern in today’s world. There are, of course, a wide range of diseases that only affect women, such as breast cancer, endometriosis, and osteoporosis. On top of that, women are more susceptible than men to various diseases. While these include sexually-transmitted diseases such as HIV, it is a little-known […]
The new study is published in the June 14, 2012 issue of the journal Cell Host & Microbe. In the new study, a team led by Scripps Research Professor Michael Oldstone showed what happened when a mouse engineered without the protein TLR7 was infected with lymphocytic choriomeningitis virus (LCMV), a virus employed to study the response of the immune […]
A type of drug that helps the body’s immune system attack tumors is showing promise. In early clinical trials involving several hundred patients with various kinds of advanced cancer, up to one-quarter of those who received the treatment saw their tumors shrink, and some are still alive more than a year later. The results are […]
Arthritis, Cancer: New Screening Technique Yields Elusive Compounds to Block Immune-Regulating Enzyme.
When I made my presentation on “Cancer, Indian & Global Scenario” at Tata Memorial Cancer Hospital, Mumbai in the year 2014, I deliberately night before the day of my presentation removed a word from one of the slides in my presentation. Now I am having hard time to recollect what that word was…. […]
Role of Magnesium in maintaining Blood Pressure and over-all well-being Magnesium an abundant mineral in the body, is naturally present in many foods, added to other food products, available as a dietary supplement, and present in some medicines (such as antacids and laxatives). Magnesium is a cofactor in more than 300 enzyme systems that regulate […]
Understanding cancer’s relationship with the human microbiome could transform immune-modulating therapies. Source: Microbes Meet Cancer | The Scientist Magazine®
An extensive look at the immune and lymphatic systems and how castor oil can benefit. Great for external use especially, cold-pressed castor oil can relieve many conditions. Source: Plethora of Health Benefits From Castor Oil
Last year we shared the study results regarding the possible cause of multiple sclerosis (MS), a study conducted by which suggests that “Lack of vitamin D may cause multiple sclerosis“. Dr Benjamin Jacobs, from the Royal National Orthopaedic hospital in London, said: “This study reveals important new evidence of a link between vitamin D deficiency and […]
Lack of vitamin D may be a direct cause of multiple sclerosis (MS), a study has found. MS occurs when the immune system attacks the protective myelin sheath that surrounds nerve fibres and acts as an insulator. Nerve signals are disrupted, leading to symptoms that can range from mild tingling sensations to full-blown paralysis. In […]
Mycobacterium tuberculosis (Mtb) induces necrosis of infected cells to evade immune responses. Recently, we found that Mtb uses the protein CpnT to kill human macrophages by secreting its C-terminal domain, named tuberculosis necrotizing toxin (TNT), which induces necrosis by an unknown mechanism. Here we show that TNT gains access to the cytosol of Mtb-infected macrophages, where it hydrolyzes the […]
Researchers have discovered that a new group of T-cells, called T memory stem cells, are susceptible to HIV and likely represent the longest-lasting cellular niche for the virus.” HIV’s devastating impact on the human immune system is due to its habit of infecting the CD4-positive T-cells that direct and support the infection-fighting activities of other immune […]