A harmony of opposite forces may defeat Diabetes.

· TGI - Health



Diabetes is a disease that affects millions of people around the world. Blood-sugar raising hormones such as glucagon counterbalance the blood- sugar lowering hormone insulin. Disrupting this delicate equilibrium can lead to diabetes.

The findings published in Cell Metabolism by Harvard researchers suggest that a chronic high-calorie diet can lead to high blood sugar simply by boosting the gut hormone activin-beta, which in turn stimulates activity of the fly version of glucagon—without affecting insulin.

Up until now researcher thought that activin-beta was produced only in the brain and peripheral nerves, but the new study reveals that endocrine cells in the midgut—at least, the midguts of flies—can make activin-beta. Further experiments fingered activin-beta as the culprit. The high-calorie diet was pushing activin-beta into overdrive, which boosted AKH, which told the fat body to release more sugar than was healthy.

Adipokinetic hormone (AKH): it is the fly equivalent of mammalian glucagon.

Fat body: the fly equivalent of the human liver and fat tissue.

Adipokinetic hormone (AKH) activity spiked in the fat body obeyed the AKH hormonal signal and released glucose into the bloodstream. The flies developed high blood sugar, insulin resistance and obesity, all similar to what happens in Type 2 diabetes.

“This activin-AKH axis is totally independent of insulin,” said Song. “It’s a different mechanism from what was known before.” “This gut-to-fat-body communication is essential for the development of high blood sugar. We didn’t know that before.”

Read more of this here


Related readings:

Good news to Diabetics: an anti-inflammatory drug ‘Salsalate’-a power packed drug (?)

July 5, 2013

Steven Shoelson, M.D., Ph.D., Head of the Section on Pathophysiology and Molecular Pharmacology and Professor of Medicine at Harvard Medical School, says that inflammation is a factor in the development of type 2 diabetes. The scientists became interested in studying salsalate, an anti-inflammatory drug, to lower blood glucose levels and the researcher Steven Shoelson targeted Type 2 Diabetes using anti-inflammatory drug Salsalate. […]

Pros & Cons of Vitamin D & Calcium Intake

February 26, 2013

Postmenopausal Women and Calcium and Vitamin D Intake  Postmenopausal women should not take supplementary calcium (1000 mg or less) and vitamin D (400 IU or less) to prevent fractures, the U.S. Preventive Services Task Force says in a new recommendation published in the Annals of Internal Medicine. Vitamin D and Older Women’s bones Older women shouldn’t […]

Watch your Carbohydrate intake

………………………………………………………because it can increase the risk of aggressive forms of breast cancer

February 7, 2013

A protein associated with conditions of metabolic imbalance, such as diabetes and obesity, may play a role in the development of aggressive forms of breast cancer, according to new findings by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and their colleagues. Metabolic imbalance is often caused by elevated […]

You Already Know How to Defeat Cancer

August 10, 2013

There are more than 100 types of Cancers. To learn about them go to: cancer.org. It appears that there is not much to panic, because the matter of the fact is that if we look at what causes cancer, it is very obvious that majority of the cancers are preventable. Look at WHAT CAUSES CANCER Inherited (Hereditary) – about […]

Explore the associations between personality traits and diet

July 29, 2013

This study was to explore the associations between food and nutrient intake, personality traits and resilience. Personality traits make up the unique combination of emotional, cognitive, and behavioral traits that characterize an individual and are relatively stable in adulthood. Personality is associated with several health outcomes, which could be explained by behavioral factors associated with […]

Focus 27: Obesity

February 28, 2014

Childhood obesity in India More than 15 million children would currently be overweight and 4 million abdominally obese in urban India. Childhood obesity is a recent epidemic with a high magnitude in India. Nine studies including 92,862 subjects were identified and analyzed. The prevalence of overweight was estimated to be 12.64% and that of obesity to […]

A Molecule That Is Produced During Exercise and contributes To The Beneficial Effects of Exercise On Metabolism : “Manipulating BAIBA — or the enzymes that generate BAIBA — may have therapeutic potential”

January 16, 2014

While it’s clear that exercise can improve health and longevity, the changes that occur in the body to facilitate these benefits are less clear. Now researchers publishing in the January issue of Cell Press journal Cell Metabolism have discovered a molecule that is produced during exercise and contributes to the beneficial effects of exercise on […]

Magnesium Rich Foods

April 9, 2014

The daily recommended amount of magnesium for an adult is 300-350mg. Along with calcium and Vitamin D one of the key nutrients that plays a role in maintaining healthy bones is Magnesium. Although there are many vitamin supplements available that include magnesium, it is fairly easy to get the necessary amounts naturally through eating magnesium rich […]

‘Influenza infection’ may play a role as causative agent of ‘pancreatitis’ and ‘diabetes’

November 5, 2012

Recent article published by Ilaria Capua in the Journal of Virology suggests that “Influenza A viruses grow in human pancreatic cells and cause pancreatitis and diabetes. It is known that ‘Influenza A’ viruses commonly cause pancreatitis in naturally and experimentally infected animals. In the current study the authors report the results of in vivo investigations carried out to establish […]


August 6, 2016

Role of Magnesium in maintaining Blood Pressure and over-all well-being Magnesium an abundant mineral in the body, is naturally present in many foods, added to other food products, available as a dietary supplement, and present in some medicines (such as antacids and laxatives). Magnesium is a cofactor in more than 300 enzyme systems that regulate […]

Malfunction of adipose mitochondria and the development of obesity and T2Diabetes

December 31, 2012

Excess of adipose tissue is accompanied by an increase in the risk of developing insulin resistance, type 2 diabetes (T2D) and other complications. Nevertheless, total or partial absence of fat or its accumulation in other tissues (lipotoxicity) is also associated to these complications. Brown adipose tissue (BAT) is considered as a thermogenic adipose tissue with […]

Selenium and Human Health

May 24, 2012

Selenium is incorporated into selenoproteins that have a wide range of pleiotropic effects, ranging from antioxidant and anti-inflammatory effects to the production of active thyroid hormone. In the past 10 years, the discovery of disease-associated polymorphisms in selenoprotein genes has drawn attention to the relevance of selenoproteins to health. Low selenium status has been associated with: 1. Increased […]

Association of the Myostatin Gene with Obesity, Abdominal Obesity and Low Lean Body Mass and in Non-Diabetic Asian Indians in North India

August 25, 2012

    Asian Indians are predisposed to develop the metabolic syndrome and type 2 diabetes (T2DM). Among other factors, a major factor contributing to metabolic risk is abnormal body composition. Asian Indians tend to have more abdominal adipose tissue, less lean body mass (LBM) and higher magnitude of insulin resistance (IR) despite falling in the […]

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

%d bloggers like this: