(Genetic) CrosstalK: Obesity -> Inflammation -> Cancer

It remains unclear how obesity worsens treatment outcomes in patients with pancreatic ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes inflammation and fibrosis. We found in mouse models of PDAC that obesity also promotes desmoplasia associated with accelerated tumor growth and impaired delivery/efficacy of chemotherapeutics through reduced perfusion. Genetic and pharmacological inhibition of angiotensin-II type-1 […]

RGD peptide-conjugated selenium nanoparticles: antiangiogenesis by suppressing VEGF-VEGFR2-ERK/AKT pathway – Nanomedicine: Nanotechnology, Biology and Medicine

ngiogenesis is essential for tumorigenesis, progression and metastasis. Herein we described the synthesis of RGD peptide-decorated and doxorubicin-loaded selenium nanoparticles (RGD-NPs) targeting tumor vasculature to enhance the cellular uptake and antiangiogenic activities in vitro and in vivo. After internalization by receptor-mediated endocytosis, this nanosystem disassembled under acidic condition with the presence of lysozymes and cell […]

Evaluation of endocytosis of silica particles used in biodegradable implants in the brain – Nanomedicine: Nanotechnology, Biology and Medicine

Silica nanoparticles embedded in a biodegradable scaffold have been proposed to offer several advantages when used in laser-tissue-soldering of blood vessels in the brain. During degradation, these nanoparticles are likely to be released into the surrounding brain tissue. The aim of this study was to investigate possible cellular uptake mechanism(s) of the two silica nanoparticle […]

Catanionic lipid nanosystems improve pharmacokinetics and anti-lung cancer activity of curcumin – Nanomedicine: Nanotechnology, Biology and Medicine

  Novel catanionic lipid nanosystems (CLNs) incorporating curcumin (CCM) were developed, and improvements in pharmacokinetics and enhanced anti-lung cancer activity were observed. CCM was present in a lipid matrix surrounded by cationic, anionic and zwitterionic surfactants, forming the core-shell nanosystems. Compared with free CCM, the CCM-CLNs had much higher oral and intravenous bioavailabilities due to […]

Quality Metrics: FDA Outlines What Data to Submit | RAPS

The technical reference document released Friday from the US Food and Drug Administration (FDA) provides recommendations to pharmaceutical companies on the submission of records and other information to support FDA’s calculation of quality metrics as part of the process validation lifecycle and pharmaceutical quality system (PQS) assessment. The 10-page guide follows the creation of an […]

Link between Atherosclerosis and Air Pollution has been Established

Link between Atherosclerosis and Air Pollution has been established   Traffic policemen and many people who run small roadside businesses spend extended hours outdoor*, like in traffic and at road junctions, are more vulnerable to the effects of exposure to Air Pollution. Long-term exposure to air pollution may increase risk of heart disease, in addition […]

Old, high-end vehicles contribute to pollution

Authors of a study recently published in Indian Journal of Applied Research, collated vehicular and pollution data from state’s agencies to show significant increase in particulate matter, ammonia and Source: Old, high-end vehicles contribute to pollution