A harmony of opposite forces may defeat Diabetes.

  Diabetes is a disease that affects millions of people around the world. Blood-sugar raising hormones such as glucagon counterbalance the blood- sugar lowering hormone insulin. Disrupting this delicate equilibrium can lead to diabetes. The findings published in Cell Metabolism by Harvard researchers suggest that a chronic high-calorie diet can lead to high blood sugar […]

Crosstalk between individual microbes and the entire cast of immune cells and genes.

Gut microbiome is a powerful regulator of disease and health and has been implicated in conditions ranging from inflammatory bowel disease to multiple sclerosis. Gut microbes engage in an intricately choreographed conversation with the immune system, stimulating it just enough to keep disease-causing invaders at bay, while at the same time reining it in so […]

Glycans in Health and Disease

When I made my presentation on “Cancer, Indian & Global Scenario” at Tata Memorial Cancer Hospital, Mumbai in the year 2014, I deliberately night before the day of my presentation removed a word from one of the slides in my presentation. Now I am having hard time to recollect what that word was….     […]

Magnesium

Role of Magnesium in maintaining Blood Pressure and over-all well-being Magnesium an abundant mineral in the body, is naturally present in many foods, added to other food products, available as a dietary supplement, and present in some medicines (such as antacids and laxatives). Magnesium is a cofactor in more than 300 enzyme systems that regulate […]

Consuming sesame-based ingredients may reduce oxidative stress

The antioxidant boosting properties of sesame, and especially sesame oil, can have a significant effect on oxidative stress, improving human health, according to a systematic review published in Journal of Medicinal Food, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Source: Consuming sesame-based ingredients may reduce oxidative stress

Potato-Heavy Diet Linked to High Blood Pressure

A new study in The BMJ on more than 187,000 people found that eating more potatoes was associated with an increased risk for hypertension. Source: Potato-Heavy Diet Linked to High Blood Pressure

(Genetic) CrosstalK: Obesity -> Inflammation -> Cancer

It remains unclear how obesity worsens treatment outcomes in patients with pancreatic ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes inflammation and fibrosis. We found in mouse models of PDAC that obesity also promotes desmoplasia associated with accelerated tumor growth and impaired delivery/efficacy of chemotherapeutics through reduced perfusion. Genetic and pharmacological inhibition of angiotensin-II type-1 […]