Driver mutations of cancer epigenomes. Roy DM1, Walsh LA, Chan TA. Protein Cell. 2014 Mar 14. [Epub ahead of print] Author information 1Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA. Abstract Epigenetic alterations are associated with all aspects of cancer, from tumor initiation to cancer progression and metastasis. It is […]
Archives for March, 2014
Cancer therapy may be too targeted Genetic landscape of rare cancer acts as a guide for future clinical trials Researchers have identified two novel cancer genes that are associated with the development of a rare, highly aggressive, cancer of blood vessels. These genes may now act as markers for future treatments and explain why narrowly […]
According to the FDA, cases of severe hepatic injury with acetaminophen occurred in patients who exceeded the prescribed dose of an acetaminophen-containing product in a 24-hour period. Because of the risk for liver damage, the FDA is now asking clinicians not to prescribe combination prescription pain relievers containing more than 325 mg of acetaminophen per […]
The development of intestinal tumors (polyps) in mice (left) was prevented by modifying the composition of gut microbes (right). It is not only genetics that predispose to bowel cancer; microbes living in the gut help drive the development of intestinal tumors, according to new research in mice published in the March issue of The Journal […]
To identify biomarkers for early identification of ambulatory persons at high short-term risk of death, the current study conducted high-throughput profiling of blood specimens in two large population-based cohorts. Background: A biomarker is a biological molecule found in blood, body fluids, or tissues that may signal an abnormal process, a condition, or a disease. The level of […]
Epidemiological studies have shown that cigarette smoking is a major risk factor for tubal ectopic pregnancy but the reason for this remains unclear. Here, the study was set out to determine the effect of smoking on Fallopian tube gene expression. An oviductal epithelial cell line (OE-E6/E7) and explants of human Fallopian tubes from non-pregnant women (n = 6) […]
The current studies investigated the potential impact of anti-vaccine conspiracy beliefs, and exposure to anti-vaccine conspiracy theories, on vaccination intentions. In Study 1: British parents completed a questionnaire measuring beliefs in anti-vaccine conspiracy theories and the likelihood that they would have a fictitious child vaccinated. Results revealed a significant negative relationship between anti-vaccine conspiracy beliefs […]
Dopaminergic PC12 cells can synthesize and release dopamine, providing a good cellular model for investigating dopamine regulation. Optogenetic stimulation of channelrhodopsin-2 provides high spatial and temporal precision for selective stimulation as a powerful neuromodulation tool for neuroscience studies. The aim of this study is to measure dopamine release from dopaminergic PC12 cells under optogenetic stimulation using electrochemical recording of self-assembled monolayers modified […]
JILA physicists used an ultrafast laser and help from German theorists to discover a new semiconductor quasiparticle, a handful of smaller particles that briefly condense into a liquid-like droplet. Quasiparticles are composites of smaller particles that can be created inside solid materials and act together in a predictable way. A simple example is the exciton, a pairing, due […]
Beating cancer is all about early detection, and new research from the Univ. of South Carolina is another step forward in catching the disease early. A team of chemists is reporting a new way to detect just a few lurking tumor cells, which can be outnumbered a billion to one in the bloodstream by healthy […]
Filariasis is a parasitic infectious tropical disease caused by thread like filarial nematodes. These worms occupy the lymph nodes and in chronic cases they lead to the disease “elephantiasis.” Over 120 million people have already been affected by it, and 40 million are seriously disfigured by this disease. These parasites in human, adopt numerous strategies to hamper […]
TGI: Thrive Health 